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Digital microfluidics: A promising technique for biochemical applications

He WANG, Liguo CHEN, Lining SUN

《机械工程前沿（英文）》 2017年第12卷第4期页码 510-525 doi: 10.1007/s11465-017-0460-z

摘要：

Digital microfluidics (DMF) is a versatile microfluidics technology that has significant application potential in the areas of automation and miniaturization. In DMF, discrete droplets containing samples and reagents are controlled to implement a series of operations via electrowetting-on-dielectric. This process works by applying electrical potentials to an array of electrodes coated with a hydrophobic dielectric layer. Unlike microchannels, DMF facilitates precise control over multiple reaction processes without using complex pump, microvalve, and tubing networks. DMF also presents other distinct features, such as portability, less sample consumption, shorter chemical reaction time, flexibility, and easier combination with other technology types. Due to its unique advantages, DMF has been applied to a broad range of fields (e.g., chemistry, biology, medicine, and environment). This study reviews the basic principles of droplet actuation, configuration design, and fabrication of the DMF device, as well as discusses the latest progress in DMF from the biochemistry perspective.

关键词： digital microfluidics electrowetting on dielectric discrete droplet biochemistry

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Porous ultrathin-shell microcapsules designed by microfluidics for selective permeation and stimuli-triggered

《化学科学与工程前沿（英文）》页码 1643-1650 doi: 10.1007/s11705-022-2201-z

摘要： Microcapsules are versatile delivery vehicles and widely used in various areas. Generally, microcapsules with solid shells lack selective permeation and only exhibit a simple release mode. Here, we use ultrathin-shell water-in-oil-in-water double emulsions as templates and design porous ultrathin-shell microcapsules for selective permeation and multiple stimuli-triggered release. After preparation of double emulsions by microfluidic devices, negatively charged shellac nanoparticles dispersed in the inner water core electrostatically complex with positively charged telechelic α,ω-diamino functionalized polydimethylsiloxane polymers dissolved in the middle oil shell at the water/oil interface, thus forming a porous shell of shellac nanoparticles cross-linked by telechelic polymers. Subsequently, the double emulsions become porous microcapsules upon evaporation of the middle oil phase. The porous ultrathin-shell microcapsules exhibit excellent properties, including tunable size, selective permeation and stimuli-triggered release. Small molecules or particles can diffuse across the shell, while large molecules or particles are encapsulated in the core, and release of the encapsulated cargos can be triggered by osmotic shock or a pH change. Due to their unique performance, porous ultrathin-shell microcapsules present promising platforms for various applications, such as drug delivery.

关键词： microcapsule emulsion microfluidics selective permeation stimuli-triggered release

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医用增材制造领域中的微流控技术 Review

王洁, 邵长敏, 王月桐, 孙凌云, 赵远锦

《工程（英文）》 2020年第6卷第11期页码 1244-1257 doi: 10.1016/j.eng.2020.10.001

摘要：

增材制造是食品、制药、医学和机械加工等领域的一种重要生产技术。得益于增材制造快速、低成本和可定制化的加工特性，医学增材制造推动了医疗器械、医学假体和临床移植物等领域的发展。在此背景下，高通量以及结构和组分把控精准等优势使微流控技术在医用增材制造领域显露头角，且已被应用于药物开发、组织工程和器官芯片的构建。本文综述了近年来微流控技术在医用增材制造领域的研究进展。首先，针对不同结构的液滴和纤维模板的构建，评估了基于微流控技术的医用增材制造的独特优势；其次，介绍了微流控技术在细胞定向、三维细胞培养、体外组织构建和细胞疗法方向的应用现状；最后，讨论了基于微流控技术的医用增材制造面临的挑战及其发展前景。

关键词：微流控生物材料增材制造液滴纤维

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Microfluidic production of liposomes through liquid–liquid phase separation in ternary droplets

《化学科学与工程前沿（英文）》 2022年第16卷第6期页码 1017-1022 doi: 10.1007/s11705-021-2118-y

摘要： Liposomes, the self-assembled phospholipid vesicles, have been extensively used in various fields such as artificial cells, drug delivery systems, biosensors and cosmetics. However, current microfluidic routes to liposomes mostly rely on water-in-oil-in-water double emulsion droplets as templates, and require complex fabrication of microfluidic devices, and tedious manipulation of multiphase fluids. Here we present a simple microfluidic approach to preparing monodisperse liposomes from oil-in-water droplets. For demonstration, we used butyl acetate-water-ethanol ternary mixtures as inner phase and an aqueous solution of surfactants as outer phase to make oil-in-water droplets, which can evolve into water-in-oil-in-water double emulsion droplets by liquid–liquid phase separation of ternary mixtures. Subsequently, the resultant water-in-oil-in-water droplets underwent a dewetting transition to form separated monodisperse liposomes and residual oil droplets, with the assistance of surfactants. The method is simple, does not require complex microfluidic devices and tedious manipulation, and provides a new platform for controllable preparation of liposomes.

关键词： microfluidics liposomes ternary droplets phase separation

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基于微流控工程的高强力学性能蛋白纤维 Review

孙静, 陈静思, 刘凯, 曾洪波

《工程（英文）》 2021年第7卷第5期页码 615-623 doi: 10.1016/j.eng.2021.02.005

摘要：

21世纪以来，研究者对轻质和高强力学性能的天然蜘蛛丝、蚕丝纤维投入了大量研究。受此研究启发，诸多人工纺丝技术（湿法纺丝、干法纺丝、电纺等）被先后开发，并用以制造坚固的蛋白纤维。然而，传统纺丝手段对所制纤维的控制能力较差。针对此问题，微流控技术已与这些技术完成良好的结合，实现了以精心设计的方式制造生物纤维，且具有操作简单和成本效益的特点。通过控制微流体通道的类型、大小、流速和剪切力，可以精确调节所制造纤维的机械行为。该技术已成功用于制造广泛的蛋白纤维，并推进了蛋白纤维的生产效率及其在各个领域的应用。本文综述了基于微流控技术的蛋白纤维的设计及制造的最新进展。首先简要讨论了天然蜘蛛丝的纺丝过程和微流控技术的纺丝过程。进而，着重讨论了通过微流控技术再生的蛋白纤维的制造及其力学性能，接着讨论了重组蛋白纤维。此外，对其他来源的蛋白纤维也进行了详细回顾。最后，对制造蛋白纤维的微流控技术的发展进行了简要总结与展望。

关键词：蛋白纤维微流控软材料生物材料

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Platform governance in the era of AI and the digital economy

《工程管理前沿（英文）》 2023年第10卷第1期页码 177-182 doi: 10.1007/s42524-022-0241-1

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Revisiting digital twins: Origins, fundamentals, and practices

《工程管理前沿（英文）》页码 668-676 doi: 10.1007/s42524-022-0216-2

摘要： The digital twins (DT) has quickly become a hot topic since it was proposed. It appears in all kinds of commercial propaganda and is widely quoted by academic circles. However, the term DT has misstatements and is misused in business and academics. This study revisits DT and defines it to be a more advanced system/product/service modeling and simulation environment that combines most modern information communication technologies (ICTs) and engineering mechanism digitization and characterized by system/product/service life cycle management, physically geometric visualization, real-time sensing and measurement of system operating conditions, predictability of system performance/safety/lifespan, and complete engineering mechanisms-based simulations. The idea of DT originates from modeling and simulation practices of engineering informatization, including virtual manufacturing (VM), model predictive control, and building information modeling (BIM). On the basis of the two-element VM model, we propose a three-element model to represent DT. DT does not have its unique technical characteristics. The existing practices of DT are extensions of the engineering informatization embracing modern ICTs. These insights clarify the origin of DT and its technical essentials.

关键词： virtual manufacturing digital twins modeling and simulation digitization computational engineering

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Development trend of urban design in “digital age”: Pan-dimensionality and individual-ubiquity

《结构与土木工程前沿（英文）》 2021年第15卷第3期页码 569-575 doi: 10.1007/s11709-021-0735-7

摘要： The wave of “digital age” featuring digital information is coming. Digital technology is profoundly changing the societal development direction and evolution paths. It also has significant bearing on production modes, social interactions and lifestyles. With regard to urban design, a system of knowledge about the creation and adaptation of material space forms that integrate humanities, art, technology and materials, digital technology has provided it with a brand-new and revolutionary scientific impetus for its evolution. The result of this evolution is “digital urban design paradigm based on human-computer interaction”, i.e., the urban development is moving toward “pan-dimensionality” and “individual ubiquity”. The future of urban design will construct a new approach to urban research and engineering, which is more complex, capable of accommodating and compatible with multiple goals of “instrumental rationality” and “value rationality”. Such a new approach shall be led by the probabilistic theory of “gray scale thinking”, reflecting quaternary synergetic view of “scientific rationality, ecological rationality, cultural rationality and technical rationality” to realize the cognitive progress of “engineering for the benefit of mankind”.

关键词： digital age urban design multiple objectives human-computer interaction pan-dimensionality individual-ubiquity

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Microfluidics for cell-cell interactions: A review

Rui Li,Xuefei Lv,Xingjian Zhang,Omer Saeed,Yulin Deng

《化学科学与工程前沿（英文）》 2016年第10卷第1期页码 90-98 doi: 10.1007/s11705-015-1550-2

摘要： Microfluidic chip has been applied in various biological fields owing to its low-consumption of reagents, high throughput, fluidic controllability and integrity. The well-designed microscale intermediary is also ideal for the study of cell biology. Particularly, microfluidic chip is helpful for better understanding cell-cell interactions. A general survey of recent publications would help to generalize the designs of the co-culture chips with different features. With ingenious and combinational utilization, the chips facilitate the implementation of some special co-culture models that are highly concerned in a different spatial and temporal way.

关键词： microfluidic chip co-culture cell-cell interactions review

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Embracing digital mindsets to ensure a sustainable future

《环境科学与工程前沿（英文）》 2023年第18卷第3期 doi: 10.1007/s11783-024-1799-0

关键词： Wildlife Climate Change Heavy metals Noise LAN Light pollution

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Design of a digital currency information system based on the UnionPay network

Hongfeng CHAI, Quan SUN, Yu ZHOU, Tao ZHU

《工程管理前沿（英文）》 2020年第7卷第4期页码 471-484 doi: 10.1007/s42524-020-0134-0

摘要： Digital currency can reduce the issuance and circulation costs of physical cash and improve the convenience and transparency of economic activities. Therefore, digital currency has received widespread attention from central banks in recent years. As an important financial infrastructure, the UnionPay network is expected to provide effective support for the construction and operation of a digital currency system. This study uses the UnionPay network as basis to systematically propose a digital currency information system from three aspects, namely, digital currency account opening, exchange, and use, and further expounds on the operation mechanism of a digital currency information system prototype. This study also discusses how to apply blockchain technology to digital currency, such as using distributed ledger for digital currency confirmation and registration and using blockchain-enabled smart contracts to realize the forward guidance function of the central bank digital currency. Lastly, the current research introduces the value of using the UnionPay network to support the operation of a digital currency information system and its technical challenges, aiming to provide beneficial guidance and reference for future research effort.

关键词： UnionPay network digital currency information system blockchain smart contracts

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Development of a novel two-stage proportional valve with a pilot digital flow distribution

Qiang GAO, Yuchuan ZHU, Changwen WU, Yulei JIANG

《机械工程前沿（英文）》 2021年第16卷第2期页码 420-434 doi: 10.1007/s11465-020-0622-2

摘要： Pilot two-stage proportional valves are widely used in high-power hydraulic systems. For the purpose of improving the dynamic performance, reliability, and digitization of the traditional proportional valve, a novel two-stage proportional valve with a pilot digital flow distribution is proposed from the viewpoint of the dual nozzle-flapper valve’s working principle. In particular, the dual nozzle-flapper is decoupled by two high-speed on/off valves (HSVs). First, the working principle and mathematical model of the proposed valve are determined. Then, the influences of the control parameters (duty cycle and switching frequency) and structural parameters (fixed orifice’s diameter and main valve’s spring) on the main valve’s motion are analyzed on the basis of theory, simulation, and experiment. In addition, in optimizing the value of the fixed orifice’s diameter, a new design criterion that considers the maximum pressure sensitivity, flow controllability, and flow linearization is proposed to improve the balance between the effective displacement and the displacement fluctuation of the main valve. The new scheme is verified by simulations and experiments. Experimental results of the closed-loop displacement tracking have demonstrated that the delay time of the main valve is always within 3.5 ms under different working conditions, and the tracking error can be significantly reduced using the higher switching frequency. The amplitude–frequency experiments indicate that a ‒3 dB-frequency of the proposed valve can reach 9.5 Hz in the case of±50% full scale and 15 Hz in the case of 0%–50% full scale. The values can be further improved by increasing the flow rate of the pilot HSV.

关键词： two-stage proportional valve digital flow distribution high-speed on/off valve position tracking characteristic dynamic performance

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Three-scale stochastic homogenization of elastic recycled aggregate concrete based on nano-indentation digital

Chen WANG, Yuching WU, Jianzhuang XIAO

《结构与土木工程前沿（英文）》 2018年第12卷第4期页码 461-473 doi: 10.1007/s11709-017-0441-7

摘要： In this paper, three-scale stochastic elastic finite element analyses are made for recycled aggregate concrete (RAC) based on nano-indentation digital images. The elastic property of RAC contains uncertainties across scales. It has both theoretical and practical values to model and predict its mechanical performance. Based on homogenization theory, effective stochastic elastic moduli of RAC at three different scales are obtained using moving window technique, nano-indentation digital images, and Monte-Carlo method. It involves the generation of a large number of random realizations of microstructure geometry based on different volume fraction of the inclusions and other parameters. The mean value, coefficient of variation and probability distribution of the effective elastic moduli are computed considering the material multiscale structure. The microscopic randomness is taken into account, and correlations of RAC among five phases are investigated. The effective elastic properties are used to obtain the global behavior of a composite structure. It is indicated that the response variability can be considerably affected by replacement percentage of recycled aggregates.

关键词： RAC nano-indentation digital image multiscale microscopic randomness homogenization

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Assessing compressive strengths of mortar and concrete from digital images by machine learning techniques

Amit SHIULY; Debabrata DUTTA; Achintya MONDAL

《结构与土木工程前沿（英文）》 2022年第16卷第3期页码 347-358 doi: 10.1007/s11709-022-0819-z

摘要： Compressive strength is the most important metric of concrete quality. Various nondestructive and semi-destructive tests can be used to evaluate the compressive strength of concrete. In the present study, a new image-based machine learning method is used to predict concrete compressive strength, including evaluation of six different models. These include support-vector machine model and various deep convolutional neural network models, namely AlexNet, GoogleNet, VGG19, ResNet, and Inception-ResNet-V2. In the present investigation, cement mortar samples were prepared using each of the cement:sand ratios of 1:3, 1:4, and 1:5, and using the water:cement ratios of 0.35 and 0.55. Cement concrete was prepared using the cement:sand:coarse aggregate ratios of 1:5:10, 1:3:6, 1:2:4, 1:1.5:3 and 1:1:2, using the water:cement ratio of 0.5 for all samples. The samples were cut, and several images of the cut surfaces were captured at various zoom levels using a digital microscope. All samples were then tested destructively for compressive strength. The images and corresponding compressive strength were then used to train machine learning models to allow them to predict compressive strength based upon the image data. The Inception-ResNet-V2 models exhibited the best predictions of compressive strength among the models tested. Overall, the present findings validated the use of machine learning models as an efficient means of estimating cement mortar and concrete compressive strengths based on digital microscopic images, as an alternative nondestructive/semi-destructive test method that could be applied at relatively less expense.

关键词： support vector machine deep convolutional neural network microscope digital image curing period

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基于液滴微流控的分级结构反蛋白石多孔支架用于仿生三维细胞共培养 Article

邵长敏, 刘羽霄, 池俊杰, 叶方富, 赵远锦

《工程（英文）》 2021年第7卷第12期页码 1778-1785 doi: 10.1016/j.eng.2020.06.031

摘要：

三维（3D）细胞培养具有更好地模拟天然组织特异性的优势，在药物开发、毒性测试和组织工程中发挥着重要作用。然而，现有的3D细胞培养的支架或微载体通常尺寸有限，并且在模拟生物体内血管复合体方面表现不佳。因此，本研究提出了一种通过简单的微流控方法制备的新型分级结构反蛋白石多孔支架，用于促进3D细胞共培养。该支架是基于微流控乳液液滴模板和惰性聚合物聚合的复合概念构建的。研究结果表明，该支架能够保证细胞培养过程中的营养供给，从而实现大面积的细胞培养。此外，通过在该支架中连续种植不同的细胞，本文还开发了内皮细胞包裹肝细胞的3D细胞共培养系统，用于构建功能化组织。研究结果表明，该支架用于细胞共培养系统，有助于维持肝细胞特定的体内功能。该分级结构反蛋白石多孔支架为3D细胞培养甚至仿生组织的构建奠定了基础。

关键词：微流控反蛋白石细胞培养液滴生物材料